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Guard Columns

Currently, chromatography production column binding capabilities are not fully used, hold times are long, and equipment only runs a small percentage of the time.  Many solutions are being investigated to improve the bioseparations platform including cycle life of production columns and continuous multicolumn processes.  The LigaTrap resins can be used as guard columns as an adjunct to improve in purification of using this approach for monoclonal antibodies.

Unlike filtering of contaminants by size exclusion technology, LigaTrap Columns use stable ligands and in cleaning protocols has harsher base sanitation than in other chromatography products.  Column life cycle is typically well over 50 cycles and well preserved despite more thorough cleaning.  These attributes result in low cost prepossessing step per cycle of use.  The columns capture wider ranges of impurities and undesired molecules protecting the more expensive production columns from them.  Therefore, being more robust than Protein A or G for purification, this preprocessing lowers costs of the production column because of fewer impurities and lowering the sample volume.  Columns are adaptable to continuous bioprocessing by being placed in the production line as a preprocessing step.

LigaTrap column residence time requirements are relatively short at 1 to 5 minutes.  In one study, “not only did the researchers find that the platform would reduce equipment costs by more than 55%, footprint by 32%, water use by 85%, buffer requirements by 58%, and overall time by 45%, but that it reduced overall unit operation costs by 21% at the 3-kg level, and by 29% at the 15-kg level, suggesting continuous downstream processes’ potential.”

The LigaTrap Guard Column is the solution.

Contact our scientists for more information on using LigaGuard columns as guard columns.

Part # Name Amount Price
LT-136-1x1ml LigaTrap Goat IgG Purification Column 1 ml $105.00 Add to Cart
LT-136-1x5ml LigaTrap Goat IgG Purification Column 1 x 5 ml $498.75 Add to Cart
LT-136-3x1ml LigaTrap Goat IgG Purification Column 3 x 1 ml $309.75 Add to Cart
LT-095-1x1ml LigaTrap Human IgG Purification Column 1 ml $105.00 Add to Cart
LT-095-1x5ml LigaTrap Human IgG Purification Column 1 x 5 ml $498.75 Add to Cart
LT-095-3x1ml LigaTrap Human IgG Purification Column 3 x 1 ml $309.75 Add to Cart
LT-137-1x1ml LigaTrap Mouse IgG Purification Column 1 ml $105.00 Add to Cart
LT-137-1x5ml LigaTrap Mouse IgG Purification Column 1 x 5 ml $498.75 Add to Cart
LT-137-3x1ml LigaTrap Mouse IgG Purification Column 3 x 1 ml $309.75 Add to Cart
LT-139-1x1ml LigaTrap Rabbit IgG Purification Column 1 ml $105.00 Add to Cart
LT-139-1x5ml LigaTrap Rabbit IgG Purification Column 1 x 5 ml $498.75 Add to Cart
LT-139-3x1ml LigaTrap Rabbit IgG Purification Column 3 x 1 ml $309.75 Add to Cart
LT-138-1x1ml LigaTrap Rat IgG Purification Column 1 ml $105.00 Add to Cart
LT-138-1x5ml LigaTrap Rat IgG Purification Column 1 x 5 ml $498.75 Add to Cart
LT-138-3x1ml LigaTrap Rat IgG Purification Column 3 x 1 ml $309.75 Add to Cart
LT-141-1x1ml LigaTrap Sheep IgG Purification Column 1 ml $105.00 Add to Cart
LT-141-1x5ml LigaTrap Sheep IgG Purification Column 1 x 5 ml $498.75 Add to Cart
LT-141-3x1ml LigaTrap Sheep IgG Purification Column 3 x 1 ml $309.75 Add to Cart
LT-144-1x1ml LigaTrap Llama IgG Purification Column 1 ml $105.00 Add to Cart
LT-144-1x5ml LigaTrap Llama IgG Purification Column 1 x 5 ml $498.75 Add to Cart
LT-144-3x1ml LigaTrap Llama IgG Purification Columns 3 x 1 ml $309.75 Add to Cart



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