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Llama IgG Resin and Columns

Like all mammals, camelids produce conventional antibodies made of 2 heavy chains and 2 light chains bound together with disulfide bonds in a Y shape (IgG1). However, they also produce two unique subclasses of immunoglobulin G, IgG2 and IgG3, also known as heavy chain IgG (hcIgG). These antibodies are made of only two heavy chains 1, that lack the CH1 region but still bear an antigen binding domain at their N-terminus called VHH.

Llama antibodies are coming into greater use due to their unique characteristics including small size.  Their steric hindrance is reduced, allowing them to reach hardly accessible antigens that conventional antibodies cannot, such as active sites of enzymes (useful to inhibit enzyme activity) as well as smaller enzymes, such as lysozymes or ribonucleases.  Additionally, Llama antibodies have the capacity to penetrate tissues compared to conventional antibodies, allowing a more precise staining of tissue sections when performing immunohistochemistry.  The high refolding capacity of the VHH region allow them to be more thermodynamically stable and resistant to high temperatures (up to 90°C / 194°F) and extreme pH conditions, such as gastric acid (pH 14).

In addition to increased yields and purity levels, LigaTrap Technologies address many of the shortfalls related to standard affinity ligands including challenges.  Our peptide ligands provide for a robust lifecycle, mild elution conditions and no immunogenicity or leaching.

Part # Name Amount Price
LT-144KIT

Llama IgG Mircospin Column Kit w/ Buffers

KIT-10x0.1mL $308.70 Add to Cart
LT-144-1ml KIT

Llama IgG 1mL Prepacked Column Kit w/ Buffers

KIT-1x1mL $236.25 Add to Cart
LT-144-5ml KIT

Llama IgG 5mL Prepacked Column Kit w/ Buffers

KIT-1x5mL $840.00 Add to Cart
LT-144

Llama IgG Loose Resin-5mL

5mL $472.50 Add to Cart
LT-144-10ml

Llama IgG Loose Resin-10mL

10mL $750.00 Add to Cart
LT-144-25ml

Llama IgG Loose Resin-25mL

25mL $959.20 Add to Cart
LT-144-50ml

Llama IgG Loose Resin-50mL

50mL $1,398.20 Add to Cart
LT-144-100ml

Llama IgG Loose Resin-100mL

100mL $1,756.00 Add to Cart
LT-144-MSC

Llama IgG Microspin Columns without buffers

10x0.1mL $131.25 Add to Cart
LT-144-1x1ml

Llama IgG Prepacked Purification Column-1mL

1x1mL $105.00 Add to Cart
LT-144-1x5ml

Llama IgG Prepacked Purification Column-5mL

1x5mL $498.75 Add to Cart
LT-144-3x1ml

Llama IgG Prepacked Purification Columns-3x1mL

3x1mL $309.75 Add to Cart

Llama IgG Yield and Purity

LigaTrap Llama IgG Purification resin stands above the competition (Protein A and Protein G) when you look at yield, recovery of all three isotypes, and aggregate reduction. All of this is accomplished using a milder pH (4.0-5.0) than Protein A and G which use very low pH elutions of 2.5-2.8. With >6X recovery compared to Protein A, use for up to 100 cycles, and the ability to bind all three Llama IgG subtypes as opposed to Protein G, makes LigaTrap Llama IgG Purification resin is a favorite amongst researchers and companies working in the Llama and Camelid IgG field.

COMPARABILITY
SDS PAGE


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