skip to Main Content

Llama IgG Resin and Columns

Like all mammals, camelids produce conventional antibodies made of 2 heavy chains and 2 light chains bound together with disulfide bonds in a Y shape (IgG1). However, they also produce two unique subclasses of immunoglobulin G, IgG2 and IgG3, also known as heavy chain IgG (hcIgG). These antibodies are made of only two heavy chains 1, that lack the CH1 region but still bear an antigen binding domain at their N-terminus called VHH.

Llama antibodies are coming into greater use due to their unique characteristics including small size.  Their steric hindrance is reduced, allowing them to reach hardly accessible antigens that conventional antibodies cannot, such as active sites of enzymes (useful to inhibit enzyme activity) as well as smaller enzymes, such as lysozymes or ribonucleases.  Additionally, Llama antibodies have the capacity to penetrate tissues compared to conventional antibodies, allowing a more precise staining of tissue sections when performing immunohistochemistry.  The high refolding capacity of the VHH region allow them to be more thermodynamically stable and resistant to high temperatures (up to 90°C / 194°F) and extreme pH conditions, such as gastric acid (pH 14).

In addition to increased yields and purity levels, LigaTrap Technologies address many of the shortfalls related to standard affinity ligands including challenges.  Our peptide ligands provide for a robust lifecycle, mild elution conditions and no immunogenicity or leaching.

Part # Name Amount Price
LT-144KIT

LigaTrap Llama IgG Kit

1 Kit $308.70 Add to Cart
LT-144-1ml KIT

LigaTrap Llama IgG Kit 1ml Column Kit

1ml KIT $236.25 Add to Cart
LT-144-5ml KIT

LigaTrap Llama IgG Kit 5ml Column Kit

5ml KIT $840.00 Add to Cart
LT-144

LigaTrap Llama IgG Resin

5 ml $472.50 Add to Cart
LT-144-10ml

LigaTrap Llama IgG Resin

10ml $750.00 Add to Cart
LT-144-25ml

LigaTrap Llama IgG Resin

25ml $959.20 Add to Cart
LT-144-50ml

LigaTrap Llama IgG Resin

50ml $1,398.20 Add to Cart
LT-144-100ml

LigaTrap Llama IgG Resin

100ml $1,756.00 Add to Cart
LT-144-MSC

LigaTrap Llama IgG MicroSpin Columns- Qty 10

MSC $131.25 Add to Cart
LT-144-1x1ml

LigaTrap Llama IgG Purification Column

1 ml $105.00 Add to Cart
LT-144-1x5ml

LigaTrap Llama IgG Purification Column

1 x 5 ml $498.75 Add to Cart
LT-144-3x1ml

LigaTrap Llama IgG Purification Columns

3 x 1 ml $309.75 Add to Cart

Llama IgG Yield and Purity

LigaTrap Llama IgG Purification resin stands above the competition (Protein A and Protein G) when you look at yield, recovery of all three isotypes, and aggregate reduction. All of this is accomplished using a milder pH (4.0-5.0) than Protein A and G which use very low pH elutions of 2.5-2.8. With >6X recovery compared to Protein A, use for up to 100 cycles, and the ability to bind all three Llama IgG subtypes as opposed to Protein G, makes LigaTrap Llama IgG Purification resin is a favorite amongst researchers and companies working in the Llama and Camelid IgG field.

COMPARABILITY
SDS PAGE


Ask A Scientist
Do you have a question about our products or services?
Fill out the form below, and one of our Scientists will get back to you with answers!
Ask A Scientist
Get In Touch With Us Today
Back To Top
Please enter your details to download the PDF