Rabbit IgG Purification Resin and Columns

Immunoglobulin G (IgG) Represents approximately 75% of serum antibodies in humans, IgG is the most common type of antibody found in blood circulation.  IgG molecules are created and released by plasma B cells. Each IgG has two antigen binding sites. Human IgG1 and IgG3 are highly active in initiating Antibody Dependent Cell-Mediated Cytotoxicity (ADCC) and Complement Dependent Cytotoxicity (CDC). In contrast, IgG2 and IgG4 are much less capable in evoking such an immune response. As a result, IgG1 and IgG3 are the most suitable for therapeutic use against cancer cells.

Normal Rabbit IgG is an isotype control antibody, which is used to estimate the non-specific binding of target primary antibodies due to Fc receptor binding or other protein-protein interactions.

Rabbit monoclonal antibody. Efforts have been ongoing for the last few decades to generate rabbit monoclonal antibodies. An antibody generated in rabbits is especially important to those antigens that are not immunogenic in rodents, which are the most commonly used host animals for monoclonal antibody production.