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IgG Purification Resin and Columns

Immunoglobulin G (IgG) Represents approximately 75% of serum antibodies in humans, IgG is the most common type of antibody found in blood circulation. IgG molecules are created and released by plasma B cells. Each IgG has two antigen binding sites. Human IgG1 and IgG3 are highly active in initiating Antibody Dependent Cell-Mediated Cytotoxicity (ADCC) and Complement Dependent Cytotoxicity (CDC). In contrast, IgG2 and IgG4 are much less capable in evoking such an immune response. As a result, IgG1 and IgG3 are the most suitable for therapeutic use against cancer cells.

Part # Name Amount Price
LT-095KIT

LigaTrap Human IgG Kit

1 Kit $294.00 Add to Cart
LT-095

LigaTrap Human IgG Resin

5 ml $450.00 Add to Cart
LT-095-1x1ml

LigaTrap® Human IgG Purification Column

1 ml $100.00 Add to Cart
LT-095-1x5ml

LigaTrap® Human IgG Purification Column

1 x 5 ml $475.00 Add to Cart
LT-095-3x1ml

LigaTrap® Human IgG Purification Column

3 x 1 ml $295.00 Add to Cart

IgG Yield and Purity

Human IgG was purified from CHO spiked media containing PBS and an 80 mg/ml load by passing the sample overLigaTrap® Human IgG resin, Pierce Plus Protein A and Pierce Protein G. TheLigaTrap® purified resin demonstrated a static binding capacity higher than Protein A and purity >95%.  Human IgG subclasses in spiked CHO media with 1% FBS compared to leading competitor Protein A and G demonstrated superior ability ofLigaTrap® Human IgG to purify IgG1 and IgG2. Three different manufacturer recommended binding conditions were used for the leading competitor of IgM purification resin.  All manufacturer recommended chromatographic protocols were followed.

COMPARABILITY
SDS PAGE


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