Rat IgM Purification Resin and Columns

With a molecular weight of 990,000 Daltons, IgM is the largest and hardest of the major antibodies commonly purified. IgM has 10 binding domains (compared to 2 for IgG antibodies) creating more affinity for the target. New IgM molecule based therapeutics are being developed as it is understood to have unique properties such as acting that act as the brain of the immune system, being an early responder to antigens and working through the complement system.

IgM monoclonal antibodies have become increasingly favorable for their use as therapeutic tools, while remaining popular for their research and diagnostic applications. Protein A and G prove to be unsuitable for IgM purification proves. LigaTrap Technologies separates itself by having the highest quality chromatographic purification for IgM on the market today. LigaTrap Rat IgM Purification Resin captures both antibody subtypes and can be reused after sanitization up to 100 times.

In addition to increased yields and purity levels, LigaTrap Technologies address many of the shortfalls related to standard affinity ligands including challenges. Our peptide ligands provide for a robust lifecycle, mild elution conditions and no immunogenicity or leaching.

This product is not recommended in serum purification applications due to cross-reactivity with other immunoglobulins. Please consult LigaTrap for protocols that may improve results in serum.